Iizuka(CLEg)R Documentation

Iizuka carcinoma data set

Description

Response is y=1 or y=-1 according as early intrahepatic recurrence or not There are 7129 gene expressions.

Data y=1 y=–1 Total
train 12 21 33
test 8 19 27

Usage

data(Iizuka)

Format

List with 4 named elements, X, y, Xt, yt, which are respectively the training design matrix, training classes, test design matrix and test classes.

Details

Hepatocellular carcinoma data set (Iizuka et al., 2003). mRNA expression profiles in tissue specimens from a training set comprising 33 patients with hepatocellular carcinoma have been hybridized with high-density oligonucleotide microarrays representing about 6000 genes. The same has been done for a blinded set of samples from 27 newly enrolled patients. Since hepatocellular carcinoma has a poor prognosis because of the high intrahepatic recurrence rate, the goal here is to predict early intrahepatic recurrence or non-recurrence. The training set consists of 33 hepatocellular carcinoma tissues of which 12 suffer from early intrahepatic recurrence and 21 not. The test set consists of 27 hepatocellular carcinoma tissues of which 8 suffer from early intrahepatic recurrence and 19 not. The number of gene expression levels is 7129.

Source

Nathalie Pochet, Frank De Smet, Johan A.K. Suykens and Bart L.R. De Moor (2004). Systematic benchmarking of microarray data classification: assessing the role of nonlinearity and dimensionality reduction. Bioinformatics Advance Access published July 1, 2004. http://homes.esat.kuleuven.be/~npochet/Bioinformatics/

References

Iizuka,N., Oka,M., Yamada-Okabe,H., Nishida,M., Maeda,Y., Mori,N., Takao,T., Tamesa,T., Tangoku,A., Tabuchi,H., Hamada,K., Nakayama,H., Ishitsuka,H., Miyamoto,T., Hirabayashi,A., Uchimura,S. and Hamamoto,Y. (2003) Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection, The Lancet, 361,923-929.

Examples

data(Iizuka)

[Package CLEg version 2.0 Index]